ea0070aep670 | Pituitary and Neuroendocrinology | ECE2020
Coopmans Eva
, Berk Kirsten AC
, El-Sayed Nour
, Neggers Sebastian
, Van der Lely Aart Jan
Objective: Acromegaly is caused by a growth hormone (GH)-secreting pituitary tumor and its signs are linked to increasedGH-dependent hepatic insulin-like growth factor I (IGF-I) synthesis. A eucaloric very low-carbohydrate ketogenic diet (euVLCK; < 50 g/day) induces ketosis and reduces portal insulin concentrations, which down-regulate hepatic GH receptors and reduce IGF-I synthesis. Somatostatin receptor ligands (SRLs) reduce GH secretion by the pituitary tumor,resul...